A New Approach to Beating Age-Related DiseasesWritten on the 2 August 2024 by Parkside InvestorPlus As Sarah blew out the candles on her 60th birthday cake, she couldn't help but wonder about the years ahead. Like many of us, she'd heard whispers of the "Big Four" diseases of aging: cardiovascular disease, cancer, diabetes, and dementia. But Sarah was determined to write a different story for her golden years. The Big Four diseases account for over 70% of all deaths globally in people over 60 (WHO, 2021). However, recent research suggests that targeting the underlying mechanisms of aging itself could be the key to preventing or delaying these conditions. One promising approach is senolytics - drugs that selectively eliminate senescent cells. A 2019 study in Nature Medicine found that a single dose of senolytics improved physical function in patients with idiopathic pulmonary fibrosis, a condition associated with accelerated aging. Another cutting-edge strategy involves boosting NAD+ levels. This crucial molecule declines with age and is linked to multiple age-related diseases. A 2018 Cell Metabolism study showed that NAD+ precursor supplementation improved cardiovascular health in older adults. Lifestyle factors remain criticalThe FINGER study demonstrated that a multi-domain intervention including diet, exercise, cognitive training, and vascular risk monitoring reduced cognitive decline by 25-150%. Surprisingly, intermittent fasting may offer protection against all four diseases. A 2019 New England Journal of Medicine review highlighted its potential to trigger cellular repair mechanisms and improve insulin sensitivity. By combining these innovative approaches with established healthy habits, we can rewrite the narrative of aging. Like Sarah, we have the power to shape our health destiny and potentially sidestep the Big Four. Remember, always consult your healthcare provider before making significant lifestyle changes or starting new supplements. At Parkside InvestorPlus, we are not health care experts, however, we can guide you on your financial health to retirement bliss, if you need any advice and guidance, contact us at Parkside InvestorPlus. Author:Parkside InvestorPlus About: As advisers, we act as a fiduciary sitting on the same side of the table as our clients, providing peace of mind, greater control and visibility. |